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Case Report
A Case of Acute Leukemia Remitted by Adding Cyclosporin-A Previously Failed with Induction Therapy
Seat Byeoul Park, Byung Kyu Choe, Heung Sik Kim, Chin Moo Kang
Clin Exp Pediatr. 2000;43(7):988-992.   Published online July 15, 2000
Clinical chemotherapy refractoriness is characterized by resistance to multiple drugs. Multidrug resistance(MDR) is caused by over-reactivity of a unidirectional drug efflux pump, transmembrane glycoprotein(P-glycoprotein), which is encoded by the MDR1 gene. P-glycoprotein leads to increased drug efflux and decreased intracellular drug concentration. Clinical trials that attempt to reverse or modulate MDR have been done. Cyclosporin-A and verapamil are the most extensively studied agents and several...
Original Article
Side Effects of Antiepileptic Drug in Children
Ick-Jin Song, Sang-Ook Nam
Clin Exp Pediatr. 1999;42(11):1559-1566.   Published online November 15, 1999
Purpose : The purpose of this study is to estimate the side effects of antiepileptic drug(AED) in children. Methods : Subjects were 267 children who had received AED for at least 1 month during January 1995 to July 1998. We reviewed their sex, age at start of seizure onset, age at medication, class and number of AED, developmental delay, type and...
Effect of Antiepileptic Drugs on Bone Metabolism and Growth in Epileptic Children
Woo Suk Juhng, Sun Jun Kim, Soo Chul Cho, Chan Uhng Joo
Clin Exp Pediatr. 1999;42(8):1078-1085.   Published online August 15, 1999
Purpose : Long-term administration of anticonvulsants for children with convulsive disorder may cause osteomalacia, depending on dosage, duration, types, and combination of anticonvulsants administered. This study was performed to examine the effect of anticonvulsant drugs on bone mineral density in epileptic children. Methods : Forty-eight epileptic children aged 3 to 15 years were enrolled in this study. They were treated with...
The Statistical Study of Patient with Acute Poisoning
Heung Pyo Kong, Kyoung Bae Park, Oh Kyung Lee, Kang Suh Park
Clin Exp Pediatr. 1997;40(11):1596-1602.   Published online November 15, 1997
Purpose : The incidence of infectious disease, which has been the cause of death in pediatric period, was decreased. But, the opportunistic exposure to toxic substance shows a tendency to increase. We performed this study in order to find out preventive measures and the latest inclination of acute poisoning in childhood. Methods : From January 1985 to July 1996, 88 children with acute drug...
Drug-Resistant Tuberculosis in Children
Seong Hee Jang, Yoon Hwa Cha, Young Min Ahn, Sang Jae Kim
Clin Exp Pediatr. 1997;40(6):818-825.   Published online June 15, 1997
Purpose : Initial drug resistance of children with tuberculosis is a useful performance indicator of tuberculosis control programme in the concerned country because it represented infection transmitted from adult patients with either primary or acquired drug resistance. But there have been a few studies available. The present study was made to know the incidence of drug-resistant tuberculosis in hopes of...
The Efficacy of Routine Liver Function Test Follow Up in Epileptic Children
Dae Hun Pee, Hyung Joo Sohn, Young Kyoo Shin, Baik Lin Eun, Sang Hee Park, Soon Kyum Kim
Clin Exp Pediatr. 1997;40(5):660-671.   Published online May 15, 1997
Purpose : Routine liver function test follow up is done in epileptic children receiving antiepileptic drugs to prevent hepatotoxicity induced by these drugs. But rarely seen are the abnormalities of liver function test, and seldomly are these abnormalities accompanied by the clinical manifestation. This study is carried out to assess the efficacy of routine liver function test follow up in...
The Hematologic Effect of Antiepileptic Drug
Dae Hun Pee, Young Kwan Park, Baik Lin Eun, Sang Hee Park, Soon Kyum Kim
Clin Exp Pediatr. 1997;40(2):217-224.   Published online February 15, 1997
Purpose : There have been controversies on the hematologic effects of antiepileptic drugs according to the mono or combined antiepileptic therapy. We evaluated the hematologic changes of the patients who have been taking antiepileptic drugs for more than 4 months and compared the changes of these values according to the mono or combined therapy. Methods : From May,1989 to April,1995, we had examined the blood...
The Clinical Study of Acute Poisoning in Children
Dae Kun Kim, Ki Cheol Choi, Eun Kyung Jung, Eun Seok Yang, Kyung Rye Moon
Clin Exp Pediatr. 1996;39(12):1753-1758.   Published online December 15, 1996
Purpose : Poisoning represents one of the most common accidents encountered by young children. Recently, mortality due to poisoning has gradually decreased, but the incidence has not decreased. We performed this study to compare the following factors during 1980's and 1990's : sex distribution, urban and rural distribution, causative substances. Methods : A clinical study was performed on 90 cases of acute poisoning who...
The Changes of Thyroid Function Tests and TSH Receptor Antibody Levels During Antithyroid Drug Therapy of Graves Disease in Children
Jeong-Ho Kim, Eun-Young Cho, Han-Wook Yoo
Clin Exp Pediatr. 1995;38(10):1404-1410.   Published online October 15, 1995
The mainstay of treatment in children with Graves' disease is antithyroid drug therapy. Most commonly used drugs are methimazole(MMI) and propylthiuracil(PTU). These drugs inhibit thyroid hormone synthesis through mechanisms that interfere with the action of thyroid peroxidase. Since antithyroid drugs are unable to inhigit the secretion of thyroid hormone which is already produced, it takes 2 to 3 weeks for...
The Side Effects of Antiepileptic drugs in Epileptic Children Treated withMonotherapy
Kon-Hee Lee, Hae-Sun Yoon
Clin Exp Pediatr. 1993;36(3):320-327.   Published online March 15, 1993
The goal of therapy of epileptic children is to control of seizures with minimal side effects of antiepileptic drug(AED). The relationship between side effects, serum levels and doses of AED were examined prospectively in 72 epileptic children who received monotherapy with phenobarbital, phenytoin, valproate, or carbamazepine for 6 to 26 months. Our results were as follows: 1) Side effects were observed in...
Effects of long-term anticonvulsant therapy of thyroid function.
Sei Joong Ko, Duk Hi Kim, Chang Jun Coe
Clin Exp Pediatr. 1989;32(11):1533-1539.   Published online November 30, 1989
Serum concentrations of total triiodothyronine (T3) and thyroxine (T4) as well as serum thyroid- stimulating hormone (TSH) were measured in 108 patients with childhood epilepsy taking anticonvul- sants and in 54 normal healthy children as control group. Of these 108 patients, 23 were treated with carbamazepine alone, 17 were phenytoin alone and the rest 68 were treated with combination of two or more drugs...
Clinical Studies on Hepatotoxicity of Antituberculous Durgs in Children.
Seong Sook Kim, Ki Sup Chung
Clin Exp Pediatr. 1985;28(5):455-462.   Published online May 31, 1985
A clinical studies were performed on hepatotoxicity of antituberculous drugs in 155 cases of tuberculous patients under 15 years who had been admitted to Pediatric Department of Yonsei University Medical Center during 4 years period between January, 1979 and December, 1982. The results were obtained as follows; 1) Hepatotoxicities were observed on 20 cases among 155 cases. They all belonged to...
The Statistical Study on Acute Drug and Chemicals Intoxication in Children.
Young Chang Kim, Hyung Jin Choi, Jae Ock Park, Dong Whan Lee, Sang Jhoo Lee
Clin Exp Pediatr. 1981;24(8):760-765.   Published online August 15, 1981
A statistical study on 135 cases of acute poisoning who were treated in Pediatric department of Soon Chun Hyang College Hospital from May, 1974 to August, 1980 was performed. The results are as follows: 1. Seasonal incidence was more prevalent in summer. (from June to August, Table 2) 2. It occurred more frequently in male than female and high incidence...
A Study on Children with Dysentery-like Stool from Taegu Area in 1980.
Yong Hoon Cho, Sung Jee Nam, Ja Hoon Koo, Doo Hong Ahn, Sung Yong Seol
Clin Exp Pediatr. 1981;24(8):735-742.   Published online August 15, 1981
A clinical and laboratory study was conducted on 75 children with dysentery-like stool, who had been admitted or visited to our pediatric department, during 8 months period from January to August 1980. The following results were obtained: One to five years of age group was affected most frequently(47%), Shigella flexneri was identified by stool culture in 23 cases(30%) and Entameba...
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